Khairul Anam, Asep Gana Suganda, Elin Yulinah Sukandar, L Broto S Kardono


Terminalia muelleri Bench is a species of family Combretaceae. This family is widely  used in traditional medicine to treat bacterial, fungal and viral infections. However, traditional use of T. muelleri is not known up to now, as well as, its pharmacological activities. It is important to test extract of T.muelleri against several microbes. Extraction of leaf of T.muelleri using solvents of increasing polarity, namely, n-hexane, ethyl acetate and methanol respectively, yielded dry extracts. The extracts were tested for antifungal and antibacterial activity. Extract of the leaf of T. muelleri exhibited antibacterial activity against standard strains of Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 and the fungi, Candida albicans ATCC 10231. Ethyl acetate extract exhibited the strongest activity against booth bacteria and fungi. This extract had MIC 0,1 μg/ml; 0,01 μg/ml; 0,1 μg/ml against S.aureus, E.coli, and C.albicans, respectively. Activity of 100 μg ethyl acetate extracts equal to 0.071 μg and 0.426 μg tetracycline HCl against S.aureus, E.coli, and respectively, and 0.0027 μg ketoconazole against C.albicans. The extract proved broad spectrum of activity against Gram positive bacteria i.e.S.aureus, Gram negative bacteria i.e, E.coli and fungi i.e.C.albicans.

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